Nina Kostina, PhD
Postdoctoral Researcher
Inspired by the fascinating properties of cell membrane to perform myriad biological functions, Nina aims to build new fully synthetic models of cell membrane. She focuses on the development of new concepts for vesicles in which their properties can be controlled by the molecular structure of the membrane-forming molecules - amphiphiles. She wants to utilize these vesicles to study complex cellular properties and program basic activities that do not necessarily mimic life.
Publications
Glycan-driven formation of raft-like domains with hierarchical periodic nanoarrays on dendrimersome synthetic cells
Wagner, A. M.; Kostina, N. Y.; Xiao, Q.; Klein, M. L.; Percec, V.; Rodriguez-Emmenegger, C.
Biomacromolecules, DOI: 10.1021/acs.biomac.3c01027 (2023)
Ionic Combisomes: A New Class of Biomimetic Vesicles to Fuse with Life
Wagner, A. M.*; Quandt, J.*; Söder, D.; Garay-Sarmiento, M.; Joseph, A.; Petrovskii, V. S.; Witzdam, L.; Hammoor, T.; Steitz, P.; Haraszti, T.; Potemkin, II; Kostina, N. Y.; Herrmann, A.; Rodriguez-Emmenegger, C.
Advanced Science, 9, 2200617 (2022)
* equal contributions
Improving hemocompatibility: How can smart surfaces direct blood to fight against thrombi
Obstals, F.*; Witzdam, L.*; Garay-Sarmiento, M.; Kostina, N. Yu.; Quandt, J.; Rossaint, R.; Singh, S.; Grottke, O.; Rodriguez-Emmenegger, C.
ACS Applied Materials & Interfaces, 13, (10), 11696-11707 (2021)
* equal contributions
Enhanced concanavalin A binding to preorganized mannose nanoarrays in glycodendrimersomes revealed multivalent interactions
Kostina, N. Yu.*; Söder, D.*; Haraszti, T.; Xiao, Q.; Rahimi, K.; Patridge, B. E.; Klein, M. L.; Percec, V.; Rodriguez-Emmenegger, C.
Angewandte Chemie, 113, (15), 8433-8441 (2021)
* equal contributions
Unraveling Topology-Induced Shape Transformations in Dendrimersomes
Kostina, N. Yu.*; Wagner, A. M.*; Haraszti, T.; Rahimi, K.; Xiao,Q.; Klein, M. L.; Percec, V.; Rodriguez-Emmenegger, C.
Soft Matter (Invited paper in themed collection: Remodelling of Biomembranes, Highlighted in front cover), 17, 254-267 (2021)
* equal contributions
Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms
Li, S.; Xia, B.; Javed, B.; Hasley, W. D.; Melendez-Davila, A.; Liu, M.; Kerzner, M.; Agarwal, S.; Xiao, Q.; Torre, P.; Bermudez, J. G.; Rahimi, K.; Kostina, N. Yu.; Moeller, M.; Rodriguez-Emmenegger, C.; Klein, M. L.; Percec, V.; Good, M. C.
ACS Nano, 14, (6), 7398-7411 (2020)
Nanovesicles Displaying Functional Linear and Branched Oligomannose Self-Assembled from Sequence-Defined Janus Glycodendrimers
Xiao, Q.; Delbianco, M.; Sherman, S. E.; Reveron Perez, A. M.; Bharate, P.; Pardo-Vargas, A.; Rodriguez-Emmenegger, C.; Kostina, N. Yu.; Rahimi, K.; Söder, D.; Möller, M.; Klein, M. L.; Seeberger, P. H.; Percec, V.
PNAS, 117 (22), 11931-11939 (2020)
Membrane-Mimetic Dendrimersomes Engulf Living Bacteria via Endocytosis
Kostina, N. Yu.; Rahimi, K.; Xiao, Q.; Haraszti, T.; Dedisch, S.; Spatz, J.; Schwaneberg, U.; Klein, M. L.; Percec, V.; Moeller, M.; Rodriguez-Emmenegger, C.
Nano Letters, 19, (8), 5732-5738 (2019)
Encapsulation of Hydrophobic Components in Dendrimersomes and Decoration of Their Surface with Proteins and Nucleic Acids
Torre, P.; Xiao, Q.; Buzzacchera, I.; Sherman, S. E.; Rahimi, K.; Kostina, N. Yu.; Rodriguez-Emmenegger, C.; Möller, M.; Wilson, C. J.; Klein, M. L.; Good, M. C.; Percec, V.
Proceedings of the National Academy of Sciences, 116, (31), 15378-15385 (2019)
Encoding Biological Recognition in a Bicomponent Cell-Membrane Mimic
Rodriguez-Emmenegger, C.; Xiao, Q.; Kostina, N. Yu.; Sherman, S. E.; Rahimi, K.; Partridge, B. E.; Li, S.; Sahoo, D.; Perez, A. M. R.; Buzzacchera, I.; Han, H.; Kerzner, M.; Malhotra, I.; Möller, M.; Wilson, C. J.; Good, M. C.; Goulian, M.; Baumgart, T.; Klein, M. L.; Percec, V.
Proceedings of the National Academy of Sciences, 116 (8), 5376-5382 (2019)
Design–Functionality Relationships for Adhesion/Growth-Regulatory Galectins
Ludwig, A. K.; Michalak, M.; Xiao, Q.; Gilles, U.; Medrano, F. J.; Ma, H.; FitzGerald, F. G.; Hasley, W. D.; Melendez-Davila, A.; Liu, M.; Rahimi, K.; Kostina, N. Yu.; Rodriguez-Emmenegger, C.; Möller, M.; Lindner, I.; Kaltner, H.; Cudic, M.; Reusch, D.; Kopitz, J.; Romero, A.; Oscarson, S.; Klein, M. L.; Gabius, H. J.; Percec, V.
Proceedings of the National Academy of Sciences, 116 (8), 2837-2842 (2019)
Antifouling Microparticles to Scavenge Lipopolysaccharide from Human Blood Plasma
Vorobii, M.; Kostina, N. Yu.; Rahimi, K.; Grama, S.; Söder, S.; Pop-Georgievski, O.; Sturcova, A.; Horak, D.; Grottke, O.; Singh, S.; Rodriguez-Emmenegger, C.
Biomacromolecules, 20 (2), 959-968 (2019)
Zwitterionic Functionalizable Scaffolds with Gyroid Pore Architecture for Tissue Engineering
Kostina, N. Yu.; Blanquer, S.; Pop‐Georgievski, O.; Rahimi, K.; Dittrich, B.; Höcherl, A.; Michálek, J.; Grijpma, D. W.; Rodriguez‐Emmenegger, C.
Macromolecular Bioscience, 19, 1800403 (2019)
Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Ddendrimersomes
Buzzacchera, I.; Xiao, Q.; Han, H.; Rahimi, K.;Li, S.; Kostina, N. Yu.; Toebes, B. J.; Wilner, S.E.; Möller, M.; Rodriguez-Emmenegger, C.; Baumgart, T.; Wilson, D.A.; Wilson, C. J.; Klein, M.L.; Percec, V. Biomacromolecules, 20 (2), 712-727 (2018)
Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings
Buzzacchera, I.; Vorobii, M.; Kostina, N. Y.; de Los Santos Pereira, A.; Riedel, T.; Bruns, M.; Ogieglo, W.; Moller, M.; Wilson, C. J.; Rodriguez-Emmenegger, C.
Biomacromolecules, 18 (6), 1983-1992 (2017)
Grafting of Functional Methacrylate Polymer Brushes by Photoinduced SET-LRP
Vorobii, M.; Pop-Georgievski, O.; de los Santos Pereira, A.; Kostina, N. Yu.; Jezorek, R.; Sedlakova, Z.; Percec, V.; Rodriguez-Emmenegger, C.
Polymer Chemistry, 7 (45), 6934-6945 (2016)
Non-Fouling Biodegradable Poly(ε-caprolactone) Nanofibers for Tissue Engineering
Kostina, N. Yu.; Pop-Georgievski, O.; Bachmann, M.; Neykova,N.; Bruns, M.; Michalek, J.; Bastmeyer, M.; Rodriguez-Emmenegger, C.
Macromolecular Bioscience, 16 (1), 83-94 (2016)
Designing Molecular Printboards: A Photolithographic Platform for Recodable Surfaces
Abt, D.; Schmidt, B. V. K. J.; Pop-Georgievski, O.; Quick, A. S.; Danilov, D.; Kostina, N. Yu.; Bruns, M.; Wenzel, W.; Wegener, M.; Rodriguez-Emmenegger, C.; Barner-Kowollik, C.
Chemistry – A European Journal, 21 (38), 13186-13190 (2015)
Photo-Triggered Functionalization of Hhierachically Structured Brushes
de los Santos Pereira, A.; Kostina, N. Yu.; Bruns, M.; Rodriguez-Emmenegger, C.; Barner-Kowollik, C.
Langmuir, 31 (21), 5899-5907 (2015)
Synthesis of Non‐Fouling Poly[N‐(2‐Hydroxypropyl)methacrylamide] Brushes by Photoinduced SET-LRP
Vorobii, M.; de los Santos Pereira, A.; Pop‐Georgievski, O.; Kostina, N. Yu.; Rodriguez‐Emmenegger, C.; Percec, V.
Polymer Chemistry, 6 (23), 4210-4220. (Highlighted in the inner cover paper) (2015)
Polymer Brushes Interfacing Blood as a Route Toward High Performance Blood Contacting Devices
Surman, F.; Riedel, T.; Bruns, M.; Kostina, N. Yu.; Sedláková, Z.; Rodriguez-Emmenegger, C.
Macromolecular Biosciences, 15 (5), 636-646 (2015)
Novel Antifouling Self-Healing Poly(carboxybetaine methacrylamide-co-HEMA) Nanocomposite Hydrogels With Superior Mechanical Properties
Kostina, N. Yu.; Sharifi, S.; de los Santos Pereira, A.; Michálek, J.; Grijpma, D. W.; Rodriguez-Emmenegger, C.
Journal of Materials Chemistry B, 1 (41), 5644-5650 (2013)
Non-Fouling Hydrogels of 2-Hydroxyethyl Methacrylate and Zwitterionic Carboxybetaine (meth)acrylamides
Kostina, N. Yu.; Rodriguez-Emmenegger, C.; Houska, M.; Brynda, E.; Michalek, J.
Biomacromolecules, 13 (12), 4164-4170 (2012)
Water-Soluble Polyplexes of modified Chitosan
Kostina, N. Yu.; Gorshkova, M. Yu.; Izumrudov, V. A.
Polymer Science Series A, 53 (10), 947 (2011)